Baby Paracetamol

Paracetamol pill is a painkiller for fever in the first year of life had a 46% increased risk of asthma by the age of six or seven, The Lancet have reported.

Researchers do not know if the drug directly increases asthma risk or another underlying factor is to blame.

Experts said parents should still use the drug for high temperatures.

Increasing use of paracetamol in children has coincided with rising cases of asthma over the past 50 years, the researchers said.

The latest study, carried out in 31 countries, is the largest to date looking at paracetamol use and childhood asthma.

Parents of children aged six and seven were asked questionnaires about symptoms of asthma, eczema and related allergic conditions in addition to details on paracetamol use for fever in the child's first year of life and the past 12 months.

The results also showed that higher doses and more regular use of the drug are associated with a greater risk of developing asthma.

Analysis of current use in 103,000 children showed those who had used paracetamol more than once a month in the past year had a three-fold increased risk of asthma compared with those who had not taken the drug in the past 12 months.

Use of paracetamol was also associated with more severe asthma symptoms

Paracetamol - a popular painkiller

Paracetamol, known as acetaminophen in the United States, is a painkiller that is popular throughout the world because it is remarkably safe and it does not irritate the stomach. Paracetamol was first discovered to have both analgesic and antipyretic properties in the late nineteenth century. Prior to this, cinchona bark, which was also used to make the anti-malaria drug quinine, had been used to treat fevers. As cinchona became scarcer, people began to look for cheaper synthetic alternatives. Two of these alternative compounds were acetanilide and phenacetin, developed in 1886 and 1887 respectively.

Because a high proportion of phenacetin is converted into paracetamol in the liver, however, phenacetin required a large dosage to achieve any direct analgesic effect.

Paracetamol works as a weak prostaglandin inhibitor. It achieves this by blocking the production of prostaglandins, which are chemicals involved in the transmission of the pain message to the brain. In this regard, paracetamol is different from Aspirin and NSAIDs (non-steroidal anti-inflammatory drugs) in that it blocks the pain message at the brain and not at the source of the pain, as the others do.

Structually, paracetamol is similar to aspirin. They are both recognised by the same enzyme, which is called cyclo-oxygenase (COX). Cyclo-oxygenase serves as a pain activator, amplifying the degree of pain experienced in order to let the body know that there is a problem. It is this enzyme that is responsible for the biosynthesis of prostoglandins. By reducing the amount of prostaglandin available for synthesis, paracetamol helps relieve headache pain by reducing the dilation of the blood vessels that cause the pain. Paracetamol, however, only inhibits prostaglandin biosynthesis in the central nervous system (CNS) with little or no effect on peripheral tissues.

Paracetamol is used to relieve mild to moderate pain, including instances of tension headache, migraine headache, muscular aches, neuralgia, backache, joint pain, rheumatic pain, general pain, toothache, teething pain, and period pain. It is suitable for most people, including the elderly and young children, because it has very few side effects. Paracetamol is used to treat osteoarthritis, a type of non-inflammatory arthritis due to the "wear and tear" of the joints, because of its analgesic properties and its lack of gastrointestinal side effects. It can also help with the pain experienced by sufferers of arthritis.

Paracetamol is an antipyretic that can reduce fever by affecting the part of the brain known as the hypothalamus that regulates the temperature of the body. This is why paracetamol is included in many cough, cold and flu medications. Specifically, paracetamol has been given to children after they have been given vaccinations in order to prevent them developing post-immunisation pyrexia, or fever.

Paracetamol can be used by patients for whom NSAIDs are contraindicated, including those with asthma or peptic ulcers. Because there are few interactions with other medications, paracetamol can be taken by people with sensitivity to aspirin. Cholestyramine, which lowers high cholesterol, may reduce the rate at which paracetamol is absorbed by the gut, while Metoclopramide and Domperidone, which are used to relieve the symptoms of stomach disorders, may have the opposite effect and should be used with caution. Paracetamol has shown no propensity to be addictive, even in people who use it frequently. Long-term or regular use of paracetamol may, however, increase the anticoagulant activity of warfarin or similar anticoagulant medicines so caution may be required in these instances.

Paracetamol, however, is not useful in reducing inflammation or the swelling of the skin or joints. This is because paracetamol has no clinically useful anti-inflammatory properties.

The body rapidly absorbs Paracetamol, with the soluble form being absorbed even faster than the solid tablets. As the paracetamol is metabolised, the peak blood level remains less than 20mg/litre after a standard adult 1000mg dose. Blood serum levels will normally peak between half an hour to two hours after ingestion. The analgesic properties of paracetamol will last for around four hours. Paracetamol has a half-life of about two hours, after which it will rapidly be expelled from the body.

Because they have heard that a large dose of paracetamol can damage the liver, some people mistakenly believe that a small dose of paracetamol must therefore be able to cause minor damage to the liver. Taken long-term, in proper therapeutic doses, the liver and other organs should not be harmed by paracetamol.